Conclusions: The data suggest that NIR light may have an acute effect on reaction time and amplitude in certain subject subsets. There were no adverse events registered across the 31 subjects in the treatment group, nor in the 18 evaluable control group subjects.
OPEN FILEConclusions—This study shows that laser treatment improved behavioral performance if initiated within 6 hours of an embolic stroke and the effect of laser treatment is durable. Therefore, transcranial laser treatment may be useful to treat human stroke patients and should be further developed.
OPEN FILEThe most advanced application of NILT is for acute ischemic stroke based upon extensive preclinical and clinical studies. In laboratory settings, NILT is also being developed to treat traumatic brain injury, Alzheimer’s disease and Parkinson’s disease. There is some intriguing data in the literature that suggests that NILT may be a method to promote clinical improvement in neurodegenerative diseases where there is a common mechanistic component, mitochondrial dysfunction and energy impairment. This article will analyze and review data supporting the continued development of NILT to treat neurodegenerative diseases.
OPEN FILEThese data imply that transcranial laser stimulation could be used as a noninvasive and efficacious approach to increase brain functions such as those related to cognitive and emotional dimensions. Transcranial infrared laser stimulation has also been proven to be safe and successful at improving neurological outcome in humans in controlled clinical trials of stroke. This innovative approach could lead to the development of non-invasive, performance-enhancing interventions in healthy humans and in those in need of neuropsychological rehabilitation.
OPEN FILEThis reviewwill cover themechanisms of action of photobiomodulation to the brain, and summarize some of the key pre-clinical studies and clinical trials that have been undertaken for diverse brain disorders.
OPEN FILEBased on the data collected to date, PBM appears to be a promising treatment for depression that is safe and welltolerated. However, large randomized controlled trials are still needed to establish the safety and effectiveness of this new treatment for MDD.
OPEN FILE"This suggests that opioid peptide mechanisms mediate the analgesic action of low-intensity laser irradiation of the cranium."
OPEN FILEConclusion:Our data suggest thatNIRlaser irradiation is a promising experimental and therapeutic tool in the field of cerebral circulation research.
OPEN FILEConclusions: This study showed that non-invasive tLLLT using 10-Hz pulsed NIR laser light was as effective as Citalopram and more effective than red laser in the treatment of depressive-like behaviors and may help improve tLLLT as an alternative non-pharmacological treatments of psychological disorders such as depression.
OPEN FILEThese data presented herein make an intriguing case for the potential of multi-watt NIR laser therapy as a safe and effective modality for the treatment of TBI and possibly other neurological insults. This multi-Watt modality provides sufficient energy delivery to the skin to yield biologically meaningful fluence at the site of brain injury
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