Acute Effects of Near Infrared Light Therapy on Brain State in Healthy Subjects as Quantified by qEEG Measures
Conclusions: The data suggest that NIR light may have an acute effect on reaction time and amplitude in certain subject subsets. There were no adverse events registered across the 31 subjects in the treatment group, nor in the 18 evaluable control group subjects.
OPEN FILETranscranial Infrared Laser Therapy Improves Clinical Rating Scores After Embolic Strokes in Rabbits
Conclusions—This study shows that laser treatment improved behavioral performance if initiated within 6 hours of an embolic stroke and the effect of laser treatment is durable. Therefore, transcranial laser treatment may be useful to treat human stroke patients and should be further developed.
OPEN FILETranscranial near-infrared laser therapy applied to promote clinical recovery in acute and chronic neurodegenerative diseases
The most advanced application of NILT is for acute ischemic stroke based upon extensive preclinical and clinical studies. In laboratory settings, NILT is also being developed to treat traumatic brain injury, Alzheimer’s disease and Parkinson’s disease. There is some intriguing data in the literature that suggests that NILT may be a method to promote clinical improvement in neurodegenerative diseases where there is a common mechanistic component, mitochondrial dysfunction and energy impairment. This article will analyze and review data supporting the continued development of NILT to treat neurodegenerative diseases.
OPEN FILETranscranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans
These data imply that transcranial laser stimulation could be used as a noninvasive and efficacious approach to increase brain functions such as those related to cognitive and emotional dimensions. Transcranial infrared laser stimulation has also been proven to be safe and successful at improving neurological outcome in humans in controlled clinical trials of stroke. This innovative approach could lead to the development of non-invasive, performance-enhancing interventions in healthy humans and in those in need of neuropsychological rehabilitation.
OPEN FILEShining light on the head: Photobiomodulation for brain disorders
This reviewwill cover themechanisms of action of photobiomodulation to the brain, and summarize some of the key pre-clinical studies and clinical trials that have been undertaken for diverse brain disorders.
OPEN FILEReview of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis
Based on the data collected to date, PBM appears to be a promising treatment for depression that is safe and welltolerated. However, large randomized controlled trials are still needed to establish the safety and effectiveness of this new treatment for MDD.
OPEN FILECranial Irradiation with GaAlAs Laser Leads to Naloxone Reversible Analgesia in Rats
"This suggests that opioid peptide mechanisms mediate the analgesic action of low-intensity laser irradiation of the cranium."
OPEN FILETargeted Increase in Cerebral Blood Flow by Transcranial Near-Infrared Laser Irradiation
Conclusion:Our data suggest thatNIRlaser irradiation is a promising experimental and therapeutic tool in the field of cerebral circulation research.
OPEN FILETherapeutic Effects of 10-HzPulsed Wave Lasers in Rat Depression Model: A Comparison Between Near-Infrared and Red Wavelengths
Conclusions: This study showed that non-invasive tLLLT using 10-Hz pulsed NIR laser light was as effective as Citalopram and more effective than red laser in the treatment of depressive-like behaviors and may help improve tLLLT as an alternative non-pharmacological treatments of psychological disorders such as depression.
OPEN FILEMulti-watt near-infrared light therapy as a neuroregenerative treatment for traumatic brain injury
These data presented herein make an intriguing case for the potential of multi-watt NIR laser therapy as a safe and effective modality for the treatment of TBI and possibly other neurological insults. This multi-Watt modality provides sufficient energy delivery to the skin to yield biologically meaningful fluence at the site of brain injury
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